Renal excretion of unchanged modafinil generally accounts for less than ten% of the oral dose. Because of this when modafinil is taken by mouth, a lot less than 10% on the drug is eradicated from the human body through the urine with out becoming metabolized with the liver or other organs.
No precise dose adjustment recommended when tofacitinib coadministered with potent CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with equally reasonable CYP3A4 and potent CYP2C19 inhibitors .
This medicine is offered only with the medical professional's prescription. This products is available in the following dosage types:
Estrogen Derivatives: In people utilizing blended oral contraceptive capsules (OCP), the manufacturer recommends that people use another method of contraception, as an alternative to or in addition to OCP, during and right up until one particular month soon after finishing modafinil therapy.
Belzutifan is really a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors could increase incidence or severity of adverse outcomes. Observe for anemia and hypoxia and lessen belzutifan dose as suggested.
saquinavir will improve the amount or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
anastrozole will improve the amount or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Mysterious.
Consider this drugs concurrently day after day. Don't alter the time of day you're taking modafinil with no conversing 1st using your medical doctor. Chances are you'll consider this medication with or without foodstuff. Dosing The dose of the drugs will probably be distinct for different clients. Abide by your doctor's orders or even the Instructions over the label. The subsequent information involves only the common doses of the drugs. In case your dose is different, will not alter it Except if your health practitioner lets you know to take action.
nelfinavir will raise the level or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
stiripentol will raise the level or outcome of modafinil by impacting hepatic enzyme CYP2C19 modafinil dosage metabolism. Modify Therapy/Keep track of Intently. Think about lessening the dose of CYP2C19 substrates, if adverse reactions are seasoned when administered concomitantly with stiripentol.
Which means it has two isomers of the identical compound. Isomers are unique variations of the identical chemical.
modafinil will minimize the level or effect of cocaine topical by impacting hepatic enzyme CYP2B6 metabolism. Insignificant/Significance Not known.
primidone will minimize the extent or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Although modafinil is applied like a cognitive enhancer or "intelligent drug" among the nutritious folks searching for enhanced concentration and productivity,[14][15] its use outside clinical supervision raises considerations regarding opportunity misuse or abuse.