fedratinib will increase the amount or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Adjust dose of drugs which are CYP3A4 substrates as needed.
For oral dosage type (tablets): For narcolepsy or obstructive snooze apnea/hypopnea syndrome: Grownups and young adults 17 yrs of age and older—two hundred milligrams (mg) as soon as each day, in the morning. Your physician might boost your dose as necessary. Youngsters and youngsters younger than seventeen decades of age—Use and dose needs to be determined by your health practitioner.
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ribociclib will increase the amount or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Belzutifan is a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may raise incidence or severity of adverse outcomes. Observe for anemia and hypoxia and decrease belzutifan dose as advisable.
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mitotane decreases levels of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Mitotane is a solid inducer of cytochrome P-4503A4; keep an eye on when coadministered with CYP3A4 substrates for more info possible dosage changes.
This drug has the prospective to become abused and bring about dependence; notify your healthcare provider Should you have ever abused or been depending on Liquor, prescription medicines, or street prescription drugs.
Keep track of Intently (1)crofelemer improves levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Crofelemer has the potential to inhibit CYP3A4 at concentrations anticipated from the gut; unlikely to inhibit systemically mainly because minimally absorbed.
enzalutamide will reduce the level or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Other prescription drugs may perhaps interact with modafinil, such as prescription and above-the-counter medicines, nutritional vitamins, and herbal merchandise. Notify Just about every of your respective wellbeing treatment companies about all medicines you employ now and any medication you start or quit making use of.
rifapentine will decrease the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
In cases where by constant positive airway tension (CPAP) would be the therapy of option for abnormal sleepiness, a maximal work to take care of with CPAP for an satisfactory period of time really should be produced ahead of initiating this drug.
cenobamate will increase the level or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Carefully. Contemplate a dose reduction of CYP2C19 substrates, as clinically suitable, when used concomitantly with cenobamate.